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Clinical Publications 2020

1 Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting. Greenberg L, Ryom L, Wandeler G, Grabmeier-Pfistershammer K, Öllinger A, Neesgaard B, Stephan C, Calmy A, Rauch A, Castagna A, Spagnuolo V, Johnson M, Stingone C, Mussini C, De Wit S, Necsoi C, Campins AA, Pradier C, Stecher M, Wasmuth JC, Monforte AD, Law M, Puhr R, Chkhartishvilli N, Tsertsvadze T, Garges H, Thorpe D, Lundgren JD, Peters L, Bansi-Matharu L, Mocroft A; RESPOND Study Group.
J Acquir Immune Defic Syndr. 2020;83(3):240-250. Abstract

2 Clinical Outcomes in Persons Coinfected With Human Immunodeficiency Virus and Hepatitis C Virus: Impact of Hepatitis C Virus Treatment. Mocroft A, Lundgren J, Gerstoft J, Rasmussen LD, Bhagani S, Aho I, Pradier C, Bogner JR, Mussini C, Uberti Foppa C, Maltez F, Laguno M, Wandeler G, Falconer K, Trofimova T, Borodulina E, Jevtovic D, Bakowska E, Kase K, Kyselyova G, Haubrich R, Rockstroh JK, Peters L; EuroSIDA Study.
Clin Infect Dis. 2020;70(10):2131-2140. Abstract

3 Development and validation of a cycle-specific risk score for febrile neutropenia during chemotherapy cycles 2-6 in patients with solid cancers: The CSR FENCE score. Aagaard T, Reekie J, Roen A, Daugaard G, Specht L, Sengeløv H, Mocroft A, Lundgren J, Helleberg M.
Int J Cancer. 2020;146(2):321-328. Abstract

4 Mortality and admission to intensive care units after febrile neutropenia in patients with cancer. Aagaard, T., Reekie, J., Jørgensen, M., Roen, A., Daugaard, G., Specht, L., Sengeløv, H., Mocroft, A., Lundgren, J., Helleberg, M.
Cancer Medicine, 2020;9(9):3033-3042. Abstract

5 Use of inhaled corticosteroids and the risk of developing type 2 diabetes in patients with chronic obstructive pulmonary disease. Saeed, M. I., Eklöf, J., Achir, I., Sivapalan, P., Meteran, H., Løkke, A., Biering-Sørensen, T., Knop, F. K., Jensen, J. S.
Diabetes Obes Metab. 2020. Abstract

6 Lymphopenia and neutropenia are associated with subsequent incident proteinuria in Danish patients with systemic lupus erythematosus . Tanha, N., Hansen, R. B., Yang, J., Lange, T., Nielsen, C. T., Helleberg, M., Kamper, A., Faurschou, M., Jacobsen, S.
Scand J Rheumatol. 2020;49(2):122-130. Abstract

7 Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines. Phillips, A. N., Bansi-Matharu, L., Venter, F., Havlir, D., Pozniak, A., Kuritzkes, D. R., Wensing, A., Lundgren, J. D., Pillay, D., Mellors, J., Cambiano, V., Jahn, A., Apollo, T., Mugurungi, O., Ripin, D., Da Silva, J., Raizes, E., Ford, N., Siberry, G. K., Gupta, R. K., Barnabas, R., Revill, P., Cohn, J., Calmy, A., Bertagnolio, S.
Lancet HIV. 2020;7(3):e193-e200. Abstract

8 Pericardial adipose tissue volume is independently associated with HIV status and prior use of stavudine, didanosine or indinavir. Knudsen, A. D., Krebs-Demmer, L., Bjørge, N. I. D., Elming, M. B., Gelpi, M., Sigvardsen, P. E., Lebech, A., Fuchs, A., KüHL, J. T., Køber, L., Lundgren, J., Nordestgaard, B. G., Kofoed, K. F., Nielsen, S. D.
The Journal of infectious diseases. 2020. Abstract

9 Remdesivir for the Treatment of Covid-19 - Preliminary Report. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members.
N Engl J Med. 2020:NEJMoa2007764. Abstract

10 Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study. Kirkegaard-Klitbo DM, Fuchs A, Stender S, Sigvardsen PE, Kühl JT, Kofoed KF, Køber L, Nordestgaard BG, Bendtsen F, Mocroft A, Lundgren J, Nielsen SD, Benfield T.
Infect Dis. 2020:jiaa246. Abstract

11 Cutaneous leishmaniasis with secondary mucosal disease in a traveller due to Leishmania (Viannia) braziliensis. Crone, C. G., Helleberg, M.
Journal of Travel Medicine. 2020. Abstract

12 Prevalence of and Risk Factors for Low Bone Mineral Density Assessed by Quantitative Computed Tomography in People Living With HIV and Uninfected Controls . Thomsen, M. T., Wiegandt, Y. L., Gelpi, M., Knudsen, A. D., Fuchs, A., Sigvardsen, P. E., Kühl, J. T., Nordestgaard, B., Køber, L., Lundgren, J., Hansen, A. E., Kofoed, K. F., Jensen, J. B., Nielsen, S. D.
J Acquir Immune Defic Syndr. 2020;83(2):165-172. Abstract

13 Risk factors during pregnancy and birth-related complications in HIV-positive versus HIV-negative women in Denmark, 2002-2014. Ørbaek, M., Thorsteinsson, K., Moseholm Larsen, E., Katzenstein, T. L., Storgaard, M., Johansen, I. S., Pedersen, G., Bach, D., Helleberg, M., Weis, N., Lebech, A.
HIV Med. 2020;21(2):84-95. Abstract

14 International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass. Hasse, B., Hannan, M., Keller, P. M., Maurer, F. P., Sommerstein, R., Mertz, D., Wagner, D., Fernández-Hidalgo, N., Nomura, J., Manfrin, V., Bettex, D., Conte, A. H., Durante-Mangoni, E., Hing-Cheung Tang, T., Stuart, R. L., Lundgren, J., Gordon, S., Jarashow, M. C., Schreiber, P. W., Niemann, S., Kohl, T. A., Daley, C., Stewardson, A. J., Whitener, C. J., Perkins, K., Plachouras, D., Lamagni, T., Chand, M., Freiberger, T., Zweifel, S., Sander, P., Schulthess, B., Scriven, J., Sax, H., van Ingen, J., Mestres, C. A., Diekema, D., Brown-Elliott, B. A., Wallace, R. J., Baddour, L. M., Miro, J. M., Hoen, B., M. chimaera ISCVID investigators.
J Hosp Infect. 2020;104(2):214-235. Abstract

15 Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis. Ronit, A., Kirkegaard-Klitbo, D. M., Dohlmann, T. L., Lundgren, J., Sabin, C. A., Phillips, A. N., Nordestgaard, B. G., Afzal, S.
Arterioscler Thromb Vasc Biol. 2020;40(2):473-482. Abstract

16 Interstitial lung abnormalities in people with HIV infection and uninfected controls. Ronit, A., Benfield, T., Lundgren, J., Vestbo, J., Afzal, S., Nordestgaard, B. G., Kühl, J. T., Kofoed, K. F., Nielsen, S. D., Kristensen, T.
J Infect Dis. 20201; 221(12):1973-1977. Abstract

17 Machine learning can identify newly diagnosed patients with CLL at high risk of infection. Agius, R., Brieghel, C., Andersen, M. A., Pearson, A. T., Ledergerber, B., Cozzi-Lepri, A., Louzoun, Y., Andersen, C. L., Bergstedt, J., von Stemann, J. H., Jørgensen, M., Tang, M. E., Fontes, M., Bahlo, J., Herling, C. D., Hallek, M., Lundgren, J., MacPherson, C. R., Larsen, J., Niemann, C. U.
Nat Commun. 2020;11(1):363. Abstract

18 Fraction of exhaled nitric oxide levels are elevated in people living with HIV compared to uninfected controls suggesting increased eosinophilic airway inflammation. Thudium, R. F., Hughes, N. L. P., Afzal, S., Çolak, Y., Gelpi, M., Knudsen, A. D., Kirkegaard-Klitbo, D. M., Borges, Á. H., Gerstoft, J., Nordestgaard, B. G., Vestbo, J., Lundgren, J., Ronit, A., Nielsen, S. D.
Clin Infect Dis. 2020. Abstract

19 Impact of Hiv-Related Gut Microbiota Alterations on Metabolic Comorbidities. Gelpi, M., Vestad, B., Hansen, S. H., Holm, K., Drivsholm, N., Goetz, A., Kirkby, N. S., Lindegaard, B., Lebech, A., Hoel, H., Michelsen, A. E., Ueland, T., Gerstoft, J., Lundgren, J., Hov, J. R., Nielsen, S. D., Trøseid, M.
Clin Infect Dis. 2020. Abstract

20 Abdominal adipose tissue is associated with alterations in tryptophan-kynurenine metabolism and markers of systemic inflammation in people with HIV. Gelpi, M., Ueland, P. M., Trøseid, M., Mocroft, A., Lebech, A., Ullum, H., Midttun, Ø., Lundgren, J., Nielsen, S. D., Copenhagen Comorbidity in HIV Infection (COCOMO) Study.
J Infect Dis. 2020;221(3):419-427. Abstract

21 Evaluation of an electronic, patient-focused management system aimed at preventing cytomegalovirus disease following solid organ transplantation. Ekenberg, C., da Cunha-Bang, C., Lodding, I. P., Sørensen, S. S., Sengeløv, H., Perch, M., Rasmussen, A., Gustafsson, F., Wareham, N. E., Kirkby, N., Kjaer, J., Helleberg, M., Reekie, J., Lundgren, J. D.
Transpl Infect Dis. 2020. Abstract

22 Physiological abnormalities in patients admitted with acute exacerbation of COPD: an observational study with continuous monitoring. Elvekjaer, M., Aasvang, E. K., Olsen, R. M., Sørensen, H. B. D., Porsbjerg, C. M., Jensen, J., Haahr-Raunkjær, C., Meyhoff, C. S., WARD-Project Group.
J Clin Monit Comput. 2019. [Online ahead of print]. Abstract

23 Poor concordance between liver stiffness and non-invasive fibrosis scores in HIV infection without viral hepatitis. Kirkegaard-Klitbo, D. M., Bendtsen, F., Lundgren, J., Nielsen, S. D., Benfield, T., COCOMO study group.
Clin Gastroenterol Hepatol. 2019. [Online ahead of print]. Abstract

24 Tuberculosis among Patients Undergoing Solid Organ Transplantation or Dialysis in a Low-Endemic Country, 2004-2017. Helleberg, M., Cho, D., Ekenberg, C., Sørensen, S., Rix, M., Gustafsson, F., Rasmussen, A., Perch, M., Andersen, P. H. S., Lundgren, J. D., Andersen, A. B.
Tuberc Res Treat. 2020. Abstract

25 Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy. Dimopoulou, C., Lundgren, J. D., Sundal, J., Ullum, H., Aukrust, P., Nielsen, F. C., Marvig, R. L.
J Hum Genet. 2020;65(3):325-335. Abstract

26 Treatment outcomes of integrase inhibitors, boosted protease inhibitors and nonnucleoside reverse transcriptase inhibitors in antiretroviral‐naïve persons starting treatment. Mocroft, A, and RESPOND study group.
HIV Med. 2020 Abstract

27 Influence of hepatitis C virus co-infection and hepatitis C virus treatment on risk of chronic kidney disease in HIV-positive persons. A Mocroft, L Ryom, C Oprea, Q Li, A Rauch, C Boesecke, V Uzdaviniene, D Sedlacek, JM. Llibre, K Lacombe,  LN. Nielsen,  Florence, I Aho, N Chkhartishvili, J Szlavik, G Dragovic, C Leen, H Sambatakou, T Staub, M Laguno, H Elinav, J Tomazic, L Peters, for the EuroSIDA study group
AIDS. 2020;34(10):1485-1495. Abstract

28 How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium. B Neesgaard *, A Mocroft, L Greenberg, JF Larsen, G Wandeler, R Zangerle, H Günthard, C Smith, S De Wit, C Mussini, A Castagna, a D'Arminio Monforte, JJ Vehreschild, JC Wasmuth, C Pradier, N Chkhartishvili, F W.N.M. Wit, M Law, A Sönnerborg, A Bruguera, C Stephan, V Vannappagari, R Haubrich, O Kirk, D Podlekareva, J Kowalska, D Raben, J Rockstroh, L Peters, R Parades, K Grabmeier-Pfistershammer, A Scherrer, M Johnson, C Necsoi, V Borghi, C Muccini, T Tserstvadze, K Petoumenos, A Volny-Anne, J Lundgren, L Ryom, for the RESPOND study group
Microorganisms. 2020;8(8):E1164. Abstract

29 Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients. Harritshøj, L. H., Hother, C. E., Sengeløv, H., Daugaard, G., Sørensen, S. S., Jacobsen, S., Perch, M., Holm, D. K., Sækmose, S. G., Aagaard, B., Erikstrup, C., Hogema, B. M., Lundgren, J. D. & Ullum, H
Int J Infect Dis. 2020;91:188-195. Abstract

30 GenAPI: a tool for gene absence-presence identification in fragmented bacterial genome sequences. Migle Gabrielaite, Rasmus L Marvig
BMC Bioinformatics. 2020;21(1):320. Abstract

31 Identifying cross-disease components of genetic risk across hospital data in the UK Biobank. Cortes A, Albers PK, Dendrou CA, Fugger L, McVean G
Nat Genet. 2020;52(1):126-134. Abstract

32 Invasive aspergillosis in patients with severe COVID-19 pneumonia. Helleberg M, Steensen M, Arendrup MC.
Clin Microbiol Infect. 2020;S1198-743X(20)30474-2, Abstract

33 Monitoring CD8a+ T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [64Cu]NOTA-CD8a PET Imaging. Kristensen LK, Christensen C, Alfsen MZ, Cold S, Nielsen CH, Kjaer A.
NMol Imaging Biol. 2020;22(4):1021-1030. Abstract

34 Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy. Helleberg M, Niemann CU, Moestrup KS, Kirk O, Lebech AM, Lane C, Lundgren J.
J Infect Dis. 2020;222(7):1103-1107. Abstract

35 Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs. Arndal E, Johansen HK, Haagensen JAJ, Bartell JA, Marvig RL, Alanin M, Aanæs K, Høiby N, Nielsen KG, Backer V, von Buchwald C.
Eur Respir J. 2020;55(1):1901472. Abstract

36 Rezafungin In Vitro Activity against Contemporary Nordic Clinical Candida Isolates and Candida auris Determined by the EUCAST Reference Method. Helleberg M, Jørgensen KM, Hare RK, Datcu R, Chowdhary A, Arendrup MC.
Antimicrob Agents Chemother. 2020;64(4):e02438-19. Abstract

37 Role of inflammatory biomarkers in the prevalence and incidence of hypertension among HIV-positive participants in the START trial. Ghazi L, Baker JV, Sharma S, Jain MK, Palfreeman A, Necsoi C, Murray DD, Neaton JD, Drawz PE for the INSIGHT START study group. 
Am J Hypertens 2020; 33(1):43–52. Abstract

Estimating the burden of HIV late presentation and its attributable morbidity and mortality across Europe 2010-2016. Kamilla Laut, M.D, Ph.D; Andrea Antinori; Barbara Bartmeyer; Marek Beniowski; Fabrice Bonnet; Johanna Brännström; Jordi Casabona; Antonella Castagna; Genevieve Chene; Dominique Costagliola; Antonella d'Arminio Monforte; Julia del Amo; Stephane De Wit; Gerd Faetkenheuer; Hansjakob Furrer; Jacek Gasiorowski; Corinne Jadand; Ole Kirk; Mario K Lazanas; Ignacio Suarez-Lozano; Jens Lundgren; Julia Mikhalik; Amanda Mocroft; Santiago Moreno; Cristina Mussini; Niels Obel; Dzimitry Paduta; Dorthe Raben; Peter Reiss; Andrew Riordan; Caroline A Sabin; Jelena Smidt; Carlo Torti; Tatiana Trofimova; Anna Vassilenko; Marta Vasylyev; Josiane Warszawski; Linda Wittkop; Alexei Yakovlev; Robert Zangerle 
BMC Infectious Diseases. 2020 [Ahead of print]

Influence of Hepatitis C coinfection and treatment on risk of diabetes mellitus in HIV-positive persons. Amanda Mocroft
Open Forum Infectious Diseases 2020  [Ahead of print]