Adherence study

The purpose of the Adherence study was to compare the extent of adherence across the two treatment regimens in NEAT 001.

The objectives were to compare the two treatment strategies in terms of:

• Level of adherence required for successful virologic suppression
• Relative prognostic value of adherence and plasma drug concentrations on the virological success/on occurrence of resistance mutations
• Relationship between adherence and drug-specific toxicities
• Relationship between adherence and patient-reported quality of life

All patients included in the main study participated in this ancillary study.