The German Cologne-Bonn cohort is designed as an open multicenter observational cohort and was initiated as a collaboration between the University Hospital Cologne and the University Hospital Bonn. At the same time when the first highly active antiretroviral therapy (HAART) became available in 1996, the Cologne-Bonn cohort was established by Gerd Fätkenheuer and. Bernd Salzberger (Cologne) and Jürgen Rockstroh (Bonn) to study the impact on clinical outcomes in these two cities. Demographics, medical history, laboratory parameters, detailed information about HIV-related disorders and non-HIV-related co-morbidities, hospitalizations, drug therapy as well as date and cause of death were documented on a regular basis, thereby ensuring continuous data quality. Thus, the Cologne-Bonn cohort has the ability to collaborate with other national and international HIV cohort projects (ClinSurv, ART-CC, COHERE, RESPOND).
The cohort has delivered important findings, which helped to gain a better understanding of the disease and helped to improve the quality of care and success of HIV therapy considerably. In 2013, the data of the Cologne-Bonn cohort was used to elucidate the challenges and causes of deaths of an increasingly aging HIV population. The most challenging increase in non-AIDS related deaths were observed for malignancies, which accounted for 16% of the deaths and highlighted the need for a better malignancy screening in people living with HIV.
Key RESPOND Staff:
Currently, the primary investigators and data managers of the cohort are Gerd Fätkenheuer, Clara Lehmann and Jörg Janne Vehreschild from the University Hospital Cologne and Jürgen Rockstroh and Jan-Christian.Wasmuth from the University Hospital Bonn.