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The purpose of this substudy is to investigate if immediate initiation of ART alters the rate of lung function decline compared to deferral of ART in HIV-1 infected persons who are antiretroviral naïve with a CD4+ count above 500 cells/mm3.

The co-enrolment goal of 1000 participants was reached in September 2013. Participants will be followed to the common closing date of the START study.